rs719725

A SNP on chromosome 9. Its most notable genotype is A;A: 1.46x increased risk for colorectal cancer

Gene
None listed
Location
Chr 96,365,683 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated1.46x increased risk for colorectal cancerTypical · 0.049% of people
  2. A;CNot rated1.5x increased risk for colorectal cancerTypical · 0.040% of people
  3. C;CNot ratednormalTypical · 0.011% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 49% A;C 40% C;C 11%
  • European ancestry (Utah)A;A 37% A;C 45% C;C 19%
  • Han Chinese (Beijing)A;A 64% A;C 27% C;C 9%
  • Japanese (Tokyo)A;A 46% A;C 46% C;C 9%
  • Yoruba (Nigeria)A;A 49% A;C 43% C;C 8%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs719725 is a SNP on chromosome 9p24 that has been associated with increased risk of colorectal cancer, based on a study of 1,567 sibships from the Colon Cancer Family Registry. By genotypes, the observed risks were as follows: (A;A) versus (C;C): odds ratios, 1.46, CI: 1.06-2.02; (A;C) versus (C;C): odds ratio 1.50, CI: 1.14-1.98; p = 0.011) : gave an overall meta-analysis (n=17) OR of 1.07 (95% CI 1.03-1.12, p-trend 0.001).

Source and license

Adapted from rs719725 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.