rs10411210

A SNP in the RHPN2 gene on chromosome 19. Its most notable genotype is T;T: 1.15x increased risk of colorectal cancer

Gene
RHPN2
Location
Chr 1933,041,394 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratedNo summary available.Typical · 0.054% of people
  2. T;TMost notableBad1.15x increased risk of colorectal cancerWorth knowing · 2.110% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 54% T;T 10%
  • European ancestry (Utah)C;C 83% T;T 0%
  • Han Chinese (Beijing)C;C 64% T;T 2%
  • Japanese (Tokyo)C;C 75% T;T 2%
  • Yoruba (Nigeria)C;C 33% T;T 21%
  • African ancestry (Southwest US)C;C 35% T;T 18%
  • Chinese (Denver)C;C 67% T;T 4%
  • Gujarati IndianC;C 41% T;T 8%
  • Luhya (Kenya)C;C 27% T;T 30%
  • Mexican ancestry (Los Angeles)C;C 62% T;T 2%
  • Maasai (Kenya)C;C 26% T;T 24%
  • TuscanC;C 82% T;T 3%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 140 words

nature colorectal cancer rs10411210 RHPN2; P = 4.6 times 10-9) In a replication study of ~1,800 Swedish patients, the rs10411210(T) allele was specifically also shown to be associated with younger age of onset for colorectal cancer. Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases. Low-penetrance susceptibility variants in familial colorectal cancer. Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations. Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci. Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients. Susceptibility genetic variants associated with early-onset colorectal cancer.

Source and license

Adapted from rs10411210 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.