rs16888589
A SNP on chromosome 8. Its most notable genotype is G;G: 1.9x higher risk for colorectal cancer
- Gene
- None listed
- Location
- Chr 8116,623,363 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- FamilyTreeDNA
- Minor allele frequency
- 7%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodnormal
- A;GNot rated1.4x higher risk for colorectal cancer
- G;GMost notableNot rated1.9x higher risk for colorectal cancer
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 86% A;G 13% G;G 1%
- European ancestry (Utah)A;A 80% A;G 20% G;G 0%
- Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
- Japanese (Tokyo)A;A 100% A;G 0% G;G 0%
- Yoruba (Nigeria)A;A 73% A;G 25% G;G 2%
- African ancestry (Southwest US)A;A 84% A;G 14% G;G 2%
- Gujarati IndianA;A 84% A;G 16% G;G 0%
- Luhya (Kenya)A;A 84% A;G 16% G;G <1%
- Mexican ancestry (Los Angeles)A;A 91% A;G 7% G;G 2%
- Maasai (Kenya)A;A 82% A;G 15% G;G 3%
- TuscanA;A 87% A;G 12% G;G 1%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 150 words
rs16888589 is a SNP on ch 8q23 near the EIFH3 gene, and it appears to be able to influence the amount of EIFH3 protein made. rs16888589 may have a causative role in increasing the risk for colorectal cancer; specifically, the minor (i.e. less frequent) rs16888589(G) allele is associated with more EIFH3 protein, in turn associated with more cancerous cell growth and invasiveness. In a statistical sense, the rs16888589(G) allele is associated with a 1.4 - 2 fold increase in risk. The authors of this study also conclude that several other nearby SNPs (rs16892766 and rs11986063) that have been statistically linked to higher colorectal cancer risk are part of a tightly linked haplotype with rs16888589, i.e. they are often inherited together, but these other SNPs are not likely to be causative since on their own in in vitro experiments they do not influence EIFH3 protein amounts.
Source and license
Adapted from rs16888589 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.