rs16892766

A SNP on chromosome 8. Its most notable genotype is A;C: slight (~1.5x) increase in colorectal cancer risk

Gene
None listed
Location
Chr 8116,618,444 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
7%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in complete genomicsTypical · 0.087% of people
  2. A;CMost notableBadslight (~1.5x) increase in colorectal cancer riskWorth knowing · 2.013% of people
  3. C;CBadslight (~2x) increase in colorectal cancer riskWorth knowing · 2.0<1% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 87% A;C 13% C;C <1%
  • European ancestry (Utah)A;A 79% A;C 21% C;C 0%
  • Han Chinese (Beijing)A;A 99% A;C <1% C;C 0%
  • Japanese (Tokyo)A;A 100% A;C 0% C;C 0%
  • Yoruba (Nigeria)A;A 65% A;C 33% C;C 1%
  • African ancestry (Southwest US)A;A 86% A;C 14% C;C 0%
  • Gujarati IndianA;A 95% A;C 5% C;C 0%
  • Luhya (Kenya)A;A 83% A;C 16% C;C <1%
  • Mexican ancestry (Los Angeles)A;A 91% A;C 7% C;C 2%
  • Maasai (Kenya)A;A 83% A;C 14% C;C 4%
  • TuscanA;A 84% A;C 15% C;C 1%

Conditions, medicines and genes

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs16892766 on 8q23.3 (colorectal cancer OR 1.88, CI: 1.30–2.72, P=0.0007)

A;C

see discussion at rs16892766

C;C

see discussion at rs16892766

Source and license

Adapted from rs16892766 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.