rs1800497(G;G)

Normal (A2/A2)

Magnitude
3.0Important
Repute
Good
Frequency
41%Average of 11 populations
On SNPedia
rs1800497(C;C)Minus strand
Gene
ANKK1

Frequency

Share of people with G;G in each HapMap population.

  • European ancestry (Utah)66%
  • Tuscan60%
  • Gujarati Indian53%
  • African ancestry (Southwest US)39%
  • Maasai (Kenya)38%
  • Luhya (Kenya)38%
  • Han Chinese (Beijing)36%
  • Yoruba (Nigeria)35%
  • Japanese (Tokyo)33%
  • Chinese (Denver)29%
  • Mexican ancestry (Los Angeles)26%

Other genotypes of rs1800497

  1. A;GBadA1/A2: Bad at avoidance of errors. 0.5x lower OCD risk, 0.87x lower Tardive Diskinesia risk, higher ADHD risk. More Alcohol Dependence. Lower risk of Postoperative Nausea. Increased obesity. Bupropion is not effective for smoking cessation.Worth knowing · 2.946% of people
  2. A;AMost notableBadA1/A1: Bad at avoidance of errors. 0.25x lower OCD; 0.56x lower Tardive Diskinesia; higher ADHD; 1.4x Alcohol Dependence; lower Postoperative Nausea; Increased obesity; less pleasure response; Bupropion ineffective for smoking cessation.; 2.4x risk for adenoma recurrence.Very important · 4.013% of people

All about rs1800497

Notes

From SNPedia

Better avoidance of errors. Normal OCD risk, normal Tardive Dyskinesia risk, lower ADHD risk. Less Alcohol dependence. Higher risk of Postoperative Nausea. Lower obesity. Bupropion is effective. This DRD2 TaqIA A2/A2 version causes a normal amount of Dopamine Receptors. Learns from mistakes more easily. Men may have a higher risk of Obsessive Compulsive Disorder but lower risk of ADHD. Women have higher Persistence. Higher risk of Tardive Diskinesia when taking dopamine receptor antagonists. Lower risk of alcoholism and smoking addiction. Faster recovery from traumatic brain injury. 1.6x risk of early postoperative nausea within 6 hours of surgery. Bupropion (Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, Zyban, Voxra) works to quit smoking. Lower obesity due to increased pleasure response to food.

Source and license

Adapted from rs1800497(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.