rs143690372
A SNP in the POLE gene on chromosome 12. Its most notable genotype is C;T: High risk of colorectal cancer
- Gene
- POLE
- Location
- Chr 12132,676,616 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;TMost notableBadHigh risk of colorectal cancer
- T;TGoodcommon/normal
On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other POLE SNPs
- rs116162724C;THigh risk of colorectal cancerVery important
- rs138207610A;GHigh risk of colorectal cancerVery important
- rs200403177A;GHigh risk of colorectal cancerVery important
- rs483352909C;GMuch higher risk for colorectal cancerVery important
- rs398122515C;TPOLE associated susceptibility to colorectal cancerVery important
- rs5744760C;TLikely benign variantMinor
- rs5744857C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
aka c.839A>G, p.Lys280Arg Heterozygotes are predicted to have a significantly higher risk of colorectal cancer, based on both patient and theoretical studies.
C;T
see text and links via main rs-page
Source and license
Adapted from rs143690372 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.