rs5744760
A SNP in the POLE gene on chromosome 12. Its most notable genotype is C;T: Likely benign variant
- Gene
- POLE
- Location
- Chr 12132,676,107 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs5744760 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 6 HapMap populations.
- AverageT;T 97% C;T 3%
- European ancestry (Utah)T;T 100% C;T 0%
- Han Chinese (Beijing)T;T 100% C;T 0%
- Japanese (Tokyo)T;T 100% C;T 0%
- Yoruba (Nigeria)T;T 94% C;T 6%
- Luhya (Kenya)T;T 90% C;T 10%
- Maasai (Kenya)T;T 99% C;T 1%
Related
Other POLE SNPs
- rs116162724C;THigh risk of colorectal cancerVery important
- rs138207610A;GHigh risk of colorectal cancerVery important
- rs143690372C;THigh risk of colorectal cancerVery important
- rs200403177A;GHigh risk of colorectal cancerVery important
- rs483352909C;GMuch higher risk for colorectal cancerVery important
- rs398122515C;TPOLE associated susceptibility to colorectal cancerVery important
- rs5744857C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
c.1007A>G, p.Asn336Ser ClinVar consensus is that this variant, rs5744760(G), is likely to be benign.
C;T
Rare but likely to be benign; see text and links via main rs-page
Source and license
Adapted from rs5744760 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.