rs398122515
A SNP in the POLE gene on chromosome 12. Its most notable genotype is C;T: POLE associated susceptibility to colorectal cancer
- Gene
- POLE
- Location
- Chr 12132,643,404 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon in clinvar
- C;TMost notableBadPOLE associated susceptibility to colorectal cancer
SNPedia records rs398122515 on the minus strand: (A;A), (A;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other POLE SNPs
- rs116162724C;THigh risk of colorectal cancerVery important
- rs138207610A;GHigh risk of colorectal cancerVery important
- rs143690372C;THigh risk of colorectal cancerVery important
- rs200403177A;GHigh risk of colorectal cancerVery important
- rs483352909C;GMuch higher risk for colorectal cancerVery important
- rs5744760C;TLikely benign variantMinor
- rs5744857C;Ccommon in clinvarTypical
Notes
From SNPedia
Notes
C;T
ClinGen guidelines recommend colonoscopy every 1-3 years starting at ages 20-30; full details here.
Source and license
Adapted from rs398122515 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.