rs5744857
A SNP in the POLE gene on chromosome 12. Its most notable genotype is C;C: common in clinvar
- Gene
- POLE
- Location
- Chr 12132,659,414 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, FamilyTreeDNA
- Minor allele frequency
- 42%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs5744857 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 17%
- European ancestry (Utah)C;C 34%
- Han Chinese (Beijing)C;C 12%
- Japanese (Tokyo)C;C 7%
- Yoruba (Nigeria)C;C 3%
- African ancestry (Southwest US)C;C 19%
- Chinese (Denver)C;C 12%
- Gujarati IndianC;C 22%
- Luhya (Kenya)C;C 6%
- Mexican ancestry (Los Angeles)C;C 22%
- Maasai (Kenya)C;C 14%
- TuscanC;C 40%
Related
Other POLE SNPs
- rs116162724C;THigh risk of colorectal cancerVery important
- rs138207610A;GHigh risk of colorectal cancerVery important
- rs143690372C;THigh risk of colorectal cancerVery important
- rs200403177A;GHigh risk of colorectal cancerVery important
- rs483352909C;GMuch higher risk for colorectal cancerVery important
- rs398122515C;TPOLE associated susceptibility to colorectal cancerVery important
- rs5744760C;TLikely benign variantMinor
Source and license
Adapted from rs5744857 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.