rs2965667

A SNP on chromosome 12. Its most notable genotype is A;A: aspirin use may increase colorectal cancer risk a bit

Gene
None listed
Location
Chr 1217,291,799 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadaspirin use may increase colorectal cancer risk a bitWorth knowing · 2.0<1% of people
  2. A;TBadaspirin use may increase colorectal cancer risk a bitWorth knowing · 2.00% of people
  3. T;TGoodcommon/normal; aspirin use reduces colorectal cancer risk a bitWorth knowing · 2.099% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageA;A <1% A;T 0% T;T 99%
  • European ancestry (Utah)A;A 2% A;T 0% T;T 98%
  • Han Chinese (Beijing)A;A 0% A;T 0% T;T 100%
  • Japanese (Tokyo)A;A 0% A;T 0% T;T 100%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 180 words

rs2965667 is a SNP on chromosome 12p12.3 near the MGST1 gene. In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (4%) with either an (A;T) or (A;A) genotype were almost twice as likely to be diagnosed with colorectal cancer compared with (T;T) individuals among those taking anti-inflammatory drugs (prevalence, 28% vs 38%; (T;T) odds ratio 0.66 when taking aspirin/NSAID, CI: 0.61-0.70, p = 7.7 × 10e−33); prevalence, 35% vs 29%; (A;T) and (A;A) odds ratio 1.89 when taking aspirin/NSAID, CI: 1.27-2.81, p = .002). If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs2965667(T;T) genotypes. However, the few people who are rs2965667(A;T) or are rs2965667(A;A) should not take aspirin or NSAIDs since doing so may actually raise their colorectal risk. This same study reached somewhat similar conclusions about two other SNPs, rs10505806 and rs16973225.

A;A

see discussion at rs2965667

A;T

see discussion at rs2965667

Source and license

Adapted from rs2965667 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.