rs869312753
A SNP in the APC gene on chromosome 5. Its most notable genotype is C;T: Familial Adenomatous Polyposis
- Gene
- APC
- Location
- Chr 5112,780,820 (GRCh38)
- Highest magnitude
- 6.5Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TMost notableBadFamilial Adenomatous Polyposis
- T;TBadrisk factor for colorectal cancer?
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other APC SNPs
- rs2229992G;TFamilial Adenomatous PolyposisVery important
- rs62619935C;TFamilial Adenomatous PolyposisVery important
- rs121913331C;TFamilial Adenomatous PolyposisVery important
- rs121913333C;TFamilial Adenomatous PolyposisVery important
- rs137854568C;TFamilial Adenomatous PolyposisVery important
- rs137854569C;GFamilial Adenomatous PolyposisVery important
- rs137854572C;TFamilial Adenomatous PolyposisVery important
- rs137854575A;CFamilial Adenomatous PolyposisVery important
Notes
From SNPedia
Notes
aka cc.562C>T, p.Gln188Ter or Q188X reported in ClinVar as a susceptibility factor for colorectal cancer, presumably based on
T;T
see rs869312753
Source and license
Adapted from rs869312753 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.