rs1801155

A SNP in the APC gene on chromosome 5. Its most notable genotype is A;A: risk of colon cancer and familial adenomatous polyposis (FAP) which usually progresses to malignancy

Gene
APC
Location
Chr 5112,839,514 (GRCh38)
Highest magnitude
6.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadrisk of colon cancer and familial adenomatous polyposis (FAP) which usually progresses to malignancyVery important · 6.0
  2. A;TBadrisk of colon cancer; familial adenomatous polyposisVery important · 4.0
  3. T;TGoodcommon in complete genomicsTypical · 0.0

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other APC SNPs

All APC SNPs

Notes

From SNPedia

Show notes, about 300 words

A;A

See discussion at: Rs1801155; also known as rs28933380; related to colorectal cancer. The APC I1307K mutation is primarily found in people of Ashkenazi Jewish heritage (Jews of Eastern European or Russian ancestry). Researchers believe that 6% of Ashkenazi Jews carry this gene mutation, making them at a significantly higher risk for developing colorectal cancer. It is also found among Sephardi and Mizrahi Jews and Muslim and Christian Palestinian Arabs, as well as Negev Bedouin. Many patients with colorectal cancer experience no symptoms in the early stages. In fact, symptoms may not appear until the disease is in advanced stage. Routine colorectal screening is very important. Even children from 11 years of age should be screened if there is a family history of colorectal cancer. * APC I1307K and Colorectal Cancer - Johns Hopkins Hereditary Colorectal Cancer Website

A;T

See discussion at rs1801155. Also known as rs28933380 related to colorectal cancer. The APC I1307K mutation is primarily found in people of Ashkenazi Jewish heritage (Jews of Eastern European or Russian ancestry). Researchers believe that 6% of Ashkenazi Jews carry this gene mutation, making them at a significantly higher risk for developing colorectal cancer. It is also found among Sephardi and Mizrahi Jews and Muslim and Christian Palestinian Arabs, as well as Negev Bedouin. Many patients with colorectal cancer experience no symptoms in the early stages. In fact, symptoms may not appear until the disease is in advanced stage. Routine colorectal screening is very important. Even children from 11 years of age should be screened if there is a family history of colorectal cancer. * APC I1307K and Colorectal Cancer - Johns Hopkins Hereditary Colorectal Cancer Website

T;T

common for Caucasians on the 23andme platform

Source and license

Adapted from rs1801155 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.