rs1799732
A SNP in the DRD2 gene on chromosome 11. Its most notable genotype is -;-: less favorable clinical outcome when on antipsychotics
- Gene
- DRD2
- Location
- Chr 11113,475,529 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe
- Minor allele frequency
- 23%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- -;-Most notableBadless favorable clinical outcome when on antipsychotics
- -;GBad1.3x increased adenoma recurrence risk
- G;GGoodnormal
SNPedia records rs1799732 on the minus strand: (-;-), (-;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other DRD2 SNPs
- rs6277A;Anormal schizophrenia risk, learns NoGo fasterWorth knowing
- rs1076560A;Ainfluences working memoryWorth knowing
- rs4648317A;Aprone to higher nicotine dependence, more impulsive/sensation seekingMinor
- rs6275A;Acommon in clinvarTypical
- rs1799978T;Tcommon in clinvarTypical
- rs1800496G;Gcommon in complete genomicsTypical
- rs1801028G;Gnormal riskTypical
- rs11214606C;Ccommon on affy axiom dataTypical
Notes
From SNPedia
Show notes, about 130 words
rs1799732 is a SNP in the D2 dopamine receptor gene DRD2 gene. Although dbSNP indicates the alleles as (C) or (-) (i.e. a deletion), investigators report the alleles as (C) or (T). In a study of individuals in the Polyp Prevention Trial with any, multiple (>/=2) or advanced colorectal adenoma recurrence after 4 years, compared to those without adenoma recurrence, rs1799732(C;T) individuals were significantly associated with all adenoma recurrence (odds ratio 1.30, CI: 1.01-1.69). The authors speculate this increased risk of adenoma recurrence (and an association with colorectal cancer) may be related to SNP-associated differences in alcohol and fat intake. 23andMe blog Alcoholism related *rs1799971(A;A) severe alcoholism 2x *rs1799732(I;I) severe alcoholism 1.85x
Source and license
Adapted from rs1799732 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.