rs6277
A SNP in the DRD2 gene on chromosome 11. Its most notable genotype is A;A: normal schizophrenia risk, learns NoGo faster
- Gene
- DRD2
- Location
- Chr 11113,412,737 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 27%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GBad1.6x higher schizophrenia risk
- A;GBad1.4x higher schizophrenia risk
- A;AMost notableGoodnormal schizophrenia risk, learns NoGo faster
SNPedia records rs6277 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 73% A;G 22% A;A 6%
- European ancestry (Utah)G;G 18% A;G 59% A;A 24%
- Han Chinese (Beijing)G;G 89% A;G 11% A;A 0%
- Japanese (Tokyo)G;G 90% A;G 10% A;A 0%
- Yoruba (Nigeria)G;G 94% A;G 7% A;A 0%
Related
Conditions, medicines and genes
Other DRD2 SNPs
- rs1076560A;Ainfluences working memoryWorth knowing
- rs1799732-;-less favorable clinical outcome when on antipsychoticsWorth knowing
- rs4648317A;Aprone to higher nicotine dependence, more impulsive/sensation seekingMinor
- rs6275A;Acommon in clinvarTypical
- rs1799978T;Tcommon in clinvarTypical
- rs1800496G;Gcommon in complete genomicsTypical
- rs1801028G;Gnormal riskTypical
- rs11214606C;Ccommon on affy axiom dataTypical
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 170 words
rs6277 (957C>T, Pro319Pro) is one of several SNPs in the dopamine receptor DRD2 gene. In a study of 300+ Russian patients with schizophrenia, the rs6277(C) allele was associated with higher risk. From a pooled meta-study (total of 4 other reports plus this one) the allelic odds ratio is 1.42 (CI: 1.26-1.61, p 2 =1). gs278 reflects a gene-gene interaction between this SNP and a NR3A SNP, rs10989591, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory. C allele associated significantly (p = 0.021) with post-traumatic stress disorder in a sample of (assumedly Australian) 127 war veterans w/ 228 controls 23andMe blog people with two As at rs6277(T;T) were better at NoGo learning. http://www.pharmgkb.org/views/reports/loadVariantReport.action?variantPositionId=531850913 pharmgkb T allele associated with decrease in mRNA levels
A;A
According to 23andMe blog this genotype is better for a particular learning task.
Source and license
Adapted from rs6277 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.