rs1799978
A SNP in the DRD2 gene on chromosome 11. Its most notable genotype is T;T: common in clinvar
- Gene
- DRD2
- Location
- Chr 11113,475,629 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 11%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1799978 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 77%
- European ancestry (Utah)T;T 90%
- Han Chinese (Beijing)T;T 70%
- Japanese (Tokyo)T;T 80%
- Yoruba (Nigeria)T;T 72%
- African ancestry (Southwest US)T;T 77%
- Chinese (Denver)T;T 57%
- Gujarati IndianT;T 89%
- Luhya (Kenya)T;T 66%
- Mexican ancestry (Los Angeles)T;T 79%
- Maasai (Kenya)T;T 72%
- TuscanT;T 92%
Related
Other DRD2 SNPs
- rs6277A;Anormal schizophrenia risk, learns NoGo fasterWorth knowing
- rs1076560A;Ainfluences working memoryWorth knowing
- rs1799732-;-less favorable clinical outcome when on antipsychoticsWorth knowing
- rs4648317A;Aprone to higher nicotine dependence, more impulsive/sensation seekingMinor
- rs6275A;Acommon in clinvarTypical
- rs1800496G;Gcommon in complete genomicsTypical
- rs1801028G;Gnormal riskTypical
- rs11214606C;Ccommon on affy axiom dataTypical
Notes
From SNPedia
Notes
Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Physiogenomic analysis of localized FMRI brain activity in schizophrenia. Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants. Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
Source and license
Adapted from rs1799978 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.