rs6275
A SNP in the DRD2 gene on chromosome 11. Its most notable genotype is A;A: common in clinvar
- Gene
- DRD2
- Location
- Chr 11113,412,755 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 47%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs6275 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 28%
- European ancestry (Utah)A;A 9%
- Han Chinese (Beijing)A;A 31%
- Japanese (Tokyo)A;A 27%
- Yoruba (Nigeria)A;A 54%
- African ancestry (Southwest US)A;A 28%
- Chinese (Denver)A;A 27%
- Gujarati IndianA;A 17%
- Luhya (Kenya)A;A 58%
- Mexican ancestry (Los Angeles)A;A 7%
- Maasai (Kenya)A;A 49%
- TuscanA;A 6%
Related
Conditions, medicines and genes
Other DRD2 SNPs
- rs6277A;Anormal schizophrenia risk, learns NoGo fasterWorth knowing
- rs1076560A;Ainfluences working memoryWorth knowing
- rs1799732-;-less favorable clinical outcome when on antipsychoticsWorth knowing
- rs4648317A;Aprone to higher nicotine dependence, more impulsive/sensation seekingMinor
- rs1799978T;Tcommon in clinvarTypical
- rs1800496G;Gcommon in complete genomicsTypical
- rs1801028G;Gnormal riskTypical
- rs11214606C;Ccommon on affy axiom dataTypical
Notes
From SNPedia
Notes
rs6275/DRD2 and rs4680/COMT useful in predicting disease risk among schizophrenia patients See also rs6277.
Source and license
Adapted from rs6275 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.