rs1076560

A SNP in the DRD2 gene on chromosome 11. Its most notable genotype is A;A: influences working memory

Gene
DRD2
Location
Chr 11113,412,966 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedinfluences working memoryWorth knowing · 2.07% of people
  2. A;CNot rated1.3x increased risk for alcoholismTypical · 0.033% of people
  3. C;CGoodnormalTypical · 0.060% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 7% A;C 33% C;C 60%
  • European ancestry (Utah)A;A 2% A;C 22% C;C 76%
  • Han Chinese (Beijing)A;A 21% A;C 45% C;C 34%
  • Japanese (Tokyo)A;A 15% A;C 52% C;C 33%
  • Yoruba (Nigeria)A;A 2% A;C 14% C;C 84%
  • African ancestry (Southwest US)A;A 0% A;C 23% C;C 77%
  • Chinese (Denver)A;A 18% A;C 55% C;C 28%
  • Gujarati IndianA;A 10% A;C 35% C;C 55%
  • Luhya (Kenya)A;A <1% A;C 15% C;C 84%
  • Mexican ancestry (Los Angeles)A;A 10% A;C 55% C;C 35%
  • Maasai (Kenya)A;A 0% A;C 24% C;C 76%
  • TuscanA;A 2% A;C 23% C;C 76%

Conditions, medicines and genes

Other DRD2 SNPs

All DRD2 SNPs

Notes

From SNPedia

Notes

rs1076560 is located in intron 6 of the dopamine receptor D2 gene. In one study of Japanese males, rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles. The DRD2 risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify rs1076560 as a potentially important variable in the development of alcoholism. rs1076560 and the DAT 3'-VNTR variant influences memory Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution

Source and license

Adapted from rs1076560 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.