rs266729

A SNP in the ADIPOQ gene on chromosome 3. Its most notable genotype is G;G: 0.73x decreased risk for colorectal cancer

Gene
ADIPOQ
Location
Chr 3186,841,685 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.058% of people
  2. C;GGood0.73x decreased risk for colorectal cancerMinor · 1.834% of people
  3. G;GMost notableGood0.73x decreased risk for colorectal cancerWorth knowing · 2.08% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 58% C;G 34% G;G 8%
  • European ancestry (Utah)C;C 49% C;G 42% G;G 9%
  • Han Chinese (Beijing)C;C 51% C;G 38% G;G 11%
  • Japanese (Tokyo)C;C 48% C;G 43% G;G 9%
  • Yoruba (Nigeria)C;C 86% C;G 13% G;G 2%

Conditions, medicines and genes

Other ADIPOQ SNPs

All ADIPOQ SNPs

Notes

From SNPedia

Show notes, about 140 words

rs266729 is a SNP in the adiponectin ADIPOQ gene that may help elucidate correlations between obesity and some types of cancer. Two case-control studies including colorectal cancer patients and controls were conducted; the first case involving 441 patients and 658 controls, all of Ashkenazi Jewish ancestry, and the second including 199 patients and 199 matched (sex, age and ethnicity) controls. rs266729(G) showed decreased colorectal cancer risk in both studies; in the first, with an odds ratio of 0.72 (CI:0.55-0.95) and in the second, with an odds ratio of 0.52 (CI: 0.34-0.78). Combining the two studies led to an overall decreased colorectal cancer odds ratio of 0.73 (CI: 0.53-0.99) for this allele.jama.ama-assn.org 23andMe blog obesity and colorectal cancer (G;G) 27% lower odds

Source and license

Adapted from rs266729 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.