rs17300539
A SNP in the ADIPOQ gene on chromosome 3. Its most notable genotype is A;A: higher adiponectin levels
- Gene
- ADIPOQ
- Location
- Chr 3186,841,671 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadhigher adiponectin levels
- A;GNot ratedif obese, dieting more effective
- G;GBadincreased risk of insulin resistance
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 8 HapMap populations.
- AverageA;A <1% A;G 5% G;G 95%
- European ancestry (Utah)A;A <1% A;G 12% G;G 87%
- Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
- Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
- Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
- African ancestry (Southwest US)A;A 0% A;G 4% G;G 97%
- Gujarati IndianA;A 0% A;G 1% G;G 99%
- Mexican ancestry (Los Angeles)A;A 0% A;G 9% G;G 91%
- TuscanA;A 2% A;G 12% G;G 86%
Related
Conditions, medicines and genes
Other ADIPOQ SNPs
- rs266729G;G0.73x decreased risk for colorectal cancerWorth knowing
- rs1501299T;Tslightly lower risk of breast cancerWorth knowing
- rs2241766G;GSlightly lower risk of breast cancerWorth knowing
- rs16861194A;Acommon in complete genomicsTypical
- rs16861205G;Gcommon in complete genomicsTypical
- rs17366568G;Gcommon in complete genomicsTypical
- rs17366653T;Tcommon in complete genomicsTypical
- rs17366743T;TNo summary available.Typical
Notes
From SNPedia
Show notes, about 130 words
rs17300539, also known as -11391 G/A, is a SNP in the promoter of the adiponectin ADIPOQ gene. A small study of 180 Spanish patients with obesity concluded that rs17300539(G;G) individuals are at increased risk of insulin resistance and MetS complications compared to carriers of an (A) allele. The rs17300539(A) allele confered protection from weight regain, particularly at 32-60 weeks after the low-calorie dietary intervention, when improvement in GG subjects had disappeared A 2008 article showed higher adiponectin levels with rs17300539 (Minor A is risk allele) with strong significance P(n) = 2.6 x 10(-8) and rs822387 (Minor C allele ) wth a stronger significance of (P(n) = 3.8 x 10(-5), but neither SNP was associated with diabetes risk.
A;A
see text at Rs17300539
Source and license
Adapted from rs17300539 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.