rs1501299

A SNP in the ADIPOQ gene on chromosome 3. Its most notable genotype is T;T: slightly lower risk of breast cancer

Gene
ADIPOQ
Location
Chr 3186,853,334 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableGoodslightly lower risk of breast cancerWorth knowing · 2.011% of people
  2. G;TGoodslightly lower risk of breast cancerWorth knowing · 2.042% of people
  3. G;GNot ratedmost common genotypeTypical · 0.047% of people

SNPedia records rs1501299 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 11% G;T 42% G;G 47%
  • European ancestry (Utah)T;T 8% G;T 40% G;G 52%
  • Han Chinese (Beijing)T;T 12% G;T 41% G;G 47%
  • Japanese (Tokyo)T;T 9% G;T 44% G;G 47%
  • Yoruba (Nigeria)T;T 16% G;T 42% G;G 42%
  • African ancestry (Southwest US)T;T 14% G;T 38% G;G 48%
  • Chinese (Denver)T;T 13% G;T 43% G;G 44%
  • Gujarati IndianT;T 4% G;T 33% G;G 63%
  • Luhya (Kenya)T;T 22% G;T 45% G;G 34%
  • Mexican ancestry (Los Angeles)T;T 9% G;T 50% G;G 41%
  • Maasai (Kenya)T;T 13% G;T 49% G;G 38%
  • TuscanT;T 7% G;T 36% G;G 57%

Conditions, medicines and genes

Other ADIPOQ SNPs

All ADIPOQ SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 400 words

rs1501299, also known as c.276G>T, represents an intronic variant in the ADIPOQ gene on chromosome 3. It is perhaps the most studied of the common ADIPOQ gene variants; most studies report that the less common rs1501299(A) allele, as oriented in dbSNP, is associated with decreased cancer risk compared with the more common (C) allele. A study of 733 breast cancer cases for 10 SNPs concluded that the rs1501299(C;C) genotype (in dbSNP orientation) was at increased risk (odds ratio 1.80, CI: 1.14 - 2.85). After categorizing individuals by adiponectin signaling status, this study found that compared with low signalers (the most frequent), intermediate signalers had a 0.64x decrease in breast cancer risk (CI: 0.49–0.83), and high signalers had a 0.15x lower breast cancer risk (CI: 0.02–1.28, p(trend) = 0.001). Adiponectin signaling status was assigned as follows (as oriented in dbSNP): rs1501299(C,C) + rs2241766(T,T) = low signaler rs1501299(A,C) + rs2241766(T,T) = low signaler rs1501299(C,C) + rs2241766(G,T) = low signaler rs1501299(A,A) + rs2241766(T,T) = intermediate signaler rs1501299(A,C) + rs2241766(G,T) = intermediate signaler rs1501299(C,C) + rs2241766(G,G) = intermediate signaler rs1501299(A,C) + rs2241766(G,G) = high signaler rs1501299(A,A) + rs2241766(G,G) = high signaler rs1501299(A,A) + rs2241766(G,T) = high signaler Based on these criteria, adiponectin signaling status is now determined by genosets Gs325 and Gs326 for Promethease users. Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism as well as glucose regulation. In other words, you are a low adiponectin signaler, and thus have basically average breast cancer risk, if you have one of these combinations of alleles: *rs1501299 CC and also rs2241766 either GT or TT *rs1501299 AC and also rs2241766 TT You are an intermediate adiponectin signaler (Gs325), and thus possibly at 0.64x reduced risk of breast cancer compared to low signallers, if you have one of these combinations of alleles: * rs1501299 CC and also rs2241766 GG * rs1501299 AC and also rs2241766 GT * rs1501299 AA and also rs2241766 TT You are a high adiponectin signaler (Gs326), and thus have the lowest (perhaps 0.15x) risk if you have one of these combinations of alleles: * rs1501299 AC and also rs2241766 GG * rs1501299 AA and also rs2241766 either GG or GT This is one of the SNPs reported by NutraHacker.

Source and license

Adapted from rs1501299 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.