rs2241766

rs2241766, also known as c.45T>G, represents a synonymous variant in the ADIPOQ gene on chromosome 3. Some studies report that the less common rs1501299(G) allele, is associated with decreased cancer risk compared with the more common (T) allele. A study of 733 breast cancer cases for 10 SNPs concluded that the rs2241766(G;T) genotype, in combination with certain genotypes at rs1501299, was at reduced risk (odds ratio 0.61, CI: 0.46-0.80). After categorizing individuals by adiponectin signaling status, this study found that compared with low signalers (the most frequent), intermediate signalers had a 0.64x decrease in breast cancer risk (CI: 0.49–0.83), and high signalers had a 0.15x lower breast cancer risk (CI: 0.02–1.28, p(trend) = 0.001). Adiponectin signaling status was assigned as follows (as oriented in dbSNP): rs1501299(C,C) + rs2241766(T,T) = low signaler rs1501299(A,C) + rs2241766(T,T) = low signaler rs1501299(C,C) + rs2241766(G,T) = low signaler rs1501299(A,A) + rs2241766(T,T) = intermediate signaler rs1501299(A,C) + rs2241766(G,T) = intermediate signaler rs1501299(C,C) + rs2241766(G,G) = intermediate signaler rs1501299(A,C) + rs2241766(G,G) = high signaler rs1501299(A,A) + rs2241766(G,G) = high signaler rs1501299(A,A) + rs2241766(G,T) = high signaler Based on these criteria, adiponectin signaling status is now determined by genosets Gs325 and Gs326 for Promethease users. Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism. In other words, you are a low adiponectin signaler, and thus have basically average breast cancer risk, if you have one of these combinations of alleles: *rs1501299 CC and also rs2241766 either GT or TT *rs1501299 AC and also rs2241766 TT You are an intermediate adiponectin signaler (Gs325), and thus possibly at 0.64x reduced risk of breast cancer compared to low signallers, if you have one of these combinations of alleles: * rs1501299 CC and also rs2241766 GG * rs1501299 AC and also rs2241766 GT * rs1501299 AA and also rs2241766 TT You are a high adiponectin signaler (Gs326), and thus have the lowest (perhaps 0.15x) risk if you have one of these combinations of alleles: * rs1501299 AC and also rs2241766 GG * rs1501299 AA and also rs2241766 either GG or GT