rs1801278

A SNP in the IRS1 gene on chromosome 2. Its most notable genotype is T;T: reduced colorectal risk when combined with INSR SNP

Gene
IRS1
Location
Chr 2226,795,828 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
5%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedreduced colorectal risk when combined with INSR SNPTypical · 0.0<1% of people
  2. C;TNot ratedreduced colorectal risk when combined with INSR SNPTypical · 0.011% of people
  3. C;CGoodnormalTypical · 0.088% of people

SNPedia records rs1801278 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageT;T <1% C;T 11% C;C 88%
  • European ancestry (Utah)T;T 0% C;T 11% C;C 89%
  • Han Chinese (Beijing)T;T 0% C;T 5% C;C 95%
  • Japanese (Tokyo)T;T 2% C;T 12% C;C 86%
  • Yoruba (Nigeria)T;T 2% C;T 16% C;C 83%

Conditions, medicines and genes

Notes

From SNPedia

Notes

The INSR A-603G promoter rs1864010 SNP, which is located within a known Sp1-binding site, was associated with the risk of colorectal cancer, with carriers of the G allele having a decreased risk (odds ratios (OR) 0.71, 95% confidence interval (CI) 0.54-0.93). Carrying the variant allele of the IRS1 Gly972Arg rs1801278 SNP further decreased the risk among the INSR-603G allele carriers (OR 0.28, 95% CI 0.11-0.70) multiple myeloma *rs1801278 [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1] *rs6684439 (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0) *rs7529229 (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0) *rs8192284 (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)

Source and license

Adapted from rs1801278 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.