rs2306536

A SNP in the CHFR gene on chromosome 12. Its most notable genotype is C;C: average

Gene
CHFR
Location
Chr 12132,847,076 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedaverageTypical · 0.067% of people
  2. C;TNot rated?Typical · 0.029% of people
  3. T;TNot rated0.5x lower risk of colorectal cancerTypical · 0.04% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 67% C;T 29% T;T 4%
  • European ancestry (Utah)C;C 69% C;T 29% T;T 3%
  • Han Chinese (Beijing)C;C 87% C;T 12% T;T <1%
  • Japanese (Tokyo)C;C 94% C;T 6% T;T 0%
  • Yoruba (Nigeria)C;C 47% C;T 44% T;T 10%
  • African ancestry (Southwest US)C;C 56% C;T 40% T;T 4%
  • Chinese (Denver)C;C 87% C;T 12% T;T <1%
  • Gujarati IndianC;C 49% C;T 42% T;T 9%
  • Luhya (Kenya)C;C 60% C;T 37% T;T 3%
  • Mexican ancestry (Los Angeles)C;C 78% C;T 19% T;T 3%
  • Maasai (Kenya)C;C 58% C;T 37% T;T 5%
  • TuscanC;C 51% C;T 45% T;T 4%

Conditions, medicines and genes

Other CHFR SNPs

All CHFR SNPs

Notes

From SNPedia

Notes

rs2306536, a SNP in the CHFR gene, was found to be significantly associated with a lower risk of colorectal cancer (odd ratio 0.53, CI: 0.30-0.94), and to be significantly correlated with the absence of distant metastases, in a case/control study of ~500 Korean patients.

Source and license

Adapted from rs2306536 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.