rs7903146(T;T)

2x increased risk for Type-2 diabetes

Magnitude
3.5Important
Repute
Bad
Frequency
7%Average of 11 populations
On SNPedia
rs7903146(T;T)
Gene
TCF7L2

Frequency

Share of people with T;T in each HapMap population.

  • Tuscan16%
  • European ancestry (Utah)11%
  • Maasai (Kenya)10%
  • African ancestry (Southwest US)9%
  • Luhya (Kenya)8%
  • Gujarati Indian7%
  • Mexican ancestry (Los Angeles)7%
  • Yoruba (Nigeria)5%
  • Japanese (Tokyo)<1%
  • Han Chinese (Beijing)0%
  • Chinese (Denver)0%

Other genotypes of rs7903146

  1. C;CGoodNormal (lower) risk of Type 2 Diabetes and Gestational Diabetes.Worth knowing · 2.062% of people
  2. C;TBad1.4x increased risk for diabetes (and perhaps colon cancer).Worth knowing · 2.131% of people

All about rs7903146

Notes

From SNPedia

This genotype doubles the risk of Type-2 diabetes, PMID 17671651 and also Gestational Diabetes. Also increased risk of colo-rectal cancer. Reduced insulin secretion in the pancreas. This has been confirmed in most races. In African Americans it even affects young people.

References

Source and license

Adapted from rs7903146(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.