rs3802842

A SNP in the COLCA2 gene on chromosome 11. Its most notable genotype is C;C: >1.17x increased risk of colorectal cancer

Gene
COLCA2
Location
Chr 11111,300,984 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratednormalTypical · 0.046% of people
  2. A;CBad1.17x increased risk of colorectal cancerMinor · 1.243% of people
  3. C;CMost notableBad>1.17x increased risk of colorectal cancerWorth knowing · 2.011% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 46% A;C 43% C;C 11%
  • European ancestry (Utah)A;A 59% A;C 35% C;C 6%
  • Han Chinese (Beijing)A;A 37% A;C 47% C;C 16%
  • Japanese (Tokyo)A;A 41% A;C 52% C;C 7%
  • Yoruba (Nigeria)A;A 41% A;C 50% C;C 9%
  • African ancestry (Southwest US)A;A 35% A;C 53% C;C 12%
  • Chinese (Denver)A;A 27% A;C 53% C;C 20%
  • Gujarati IndianA;A 65% A;C 29% C;C 6%
  • Luhya (Kenya)A;A 46% A;C 33% C;C 22%
  • Mexican ancestry (Los Angeles)A;A 62% A;C 38% C;C 0%
  • Maasai (Kenya)A;A 39% A;C 46% C;C 15%
  • TuscanA;A 50% A;C 41% C;C 9%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs3802842 is a SNP in a region of ch 11q23.1 that has been associated with some cancers. IN a study of over 10,000 cases of colorectal cancer, rs3802842(C) was associated with increased risk (odds ratio 1.17, CI: 1.12-1.22, p = 1.08 x 10e-12). Additional SNPs in chromosomal regions 8q21, 8q24, 10p14, 11q, 15q13.3 and 18q21 can be combined additively to produce an overall risk, with an average odds ratio per risk allele of 1.19.

Source and license

Adapted from rs3802842 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.