rs16973225

A SNP in the LOC102724001 gene on chromosome 15. Its most notable genotype is A;A: common/normal; aspirin use reduces colorectal cancer risk a bit

Gene
LOC102724001
Location
Chr 1581,937,658 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon/normal; aspirin use reduces colorectal cancer risk a bitWorth knowing · 2.079% of people
  2. A;CBadno reduction in colorectal cancer risk from taking aspirinMinor · 1.520% of people
  3. C;CBadno reduction in colorectal cancer risk from taking aspirinMinor · 1.5<1% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 79% A;C 20% C;C <1%
  • European ancestry (Utah)A;A 89% A;C 9% C;C 2%
  • Han Chinese (Beijing)A;A 64% A;C 33% C;C 2%
  • Japanese (Tokyo)A;A 76% A;C 24% C;C 0%
  • Yoruba (Nigeria)A;A 86% A;C 14% C;C 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 160 words

rs16973225 is a SNP on chromosome 15q25.2 near the IL16 gene. In a long-term study of ~17,000 individuals and aspirin or NSAID use, the few (9%) with either an (A;C) or (C;C) genotype showed no risk reduction for colorectal cancer compared with (A;A) individuals among those taking anti-inflammatory drugs, who did benefit (prevalence, 28% vs 38%; (A;A) odds ratio 0.66 when taking aspirin/NSAID, CI: 0.62-0.71, p = 1.9 × 10e−30). If this data is robust and all other factors are equal, this indicates that most people will lower their colorectal cancer risk by taking aspirin or NSAIDs, since most people have rs16973225(A;A) genotypes. However, the few people who are rs16973225(A;C) or are rs16973225(C;C) will not change their risk one way or the other by taking aspirin. This same study reached somewhat similar conclusions about two other SNPs, rs10505806 and rs2965667.

A;A

see discussion at rs16973225

A;C

see discussion at rs16973225

C;C

see discussion at rs16973225

Source and license

Adapted from rs16973225 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.