rs3834129
A SNP in the CASP8 gene on chromosome 2. Its most notable genotype is -;CTTACT: Slightly decreased risk (0.9x) of certain cancers
- Gene
- CASP8
- Location
- Chr 2201,232,809 (GRCh38)
- Highest magnitude
- 1.1Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 40%
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;CTTACTMost notableGoodSlightly decreased risk (0.9x) of certain cancers
- CTTACT;CTTACTGoodcommon/normal
On SNPedia: (-;CTTACT), (CTTACT;CTTACT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 130 words
rs3834129 is a SNP in the CASP8 gene that is also known as the -652 6N ins/del promoter variant. It has been linked to higher risk for multiple tumours including colorectal cancer (CRC) in Chinese populations; however, it showed no association with colorectal cancer risk in a study of 4,000 UK cases. A 2012 meta-analysis found a small protective effect (i.e. slightly reduced cancer risk) associated with the rs3834129(-;CTTACT) "6N ins/del" genotype compared to the more common "6N/6N" (rs3834129(CTTACT;CTTACT)) genotype, however, there was no statistical effect noted for the "6N del/del" genotype. This page demonstrates a bug in User:SNPediaBot. It incorrectly assigned the genotype, probably because it is multiple letters. This makes a good test case.
-;CTTACT
see discussion at rs3834129
Source and license
Adapted from rs3834129 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.