rs2074190

A SNP in the TBX21 gene on chromosome 17. Its most notable genotype is G;G: 2.2x risk for AIA

Gene
TBX21
Location
Chr 1747,733,844 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
24%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot rated2.2x risk for AIATypical · 0.08% of people
  2. A;GNot rated2.2x risk for AIATypical · 0.036% of people
  3. A;ANot ratedcommonTypical · 0.056% of people

SNPedia records rs2074190 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 8% A;G 36% A;A 56%
  • European ancestry (Utah)G;G 4% A;G 39% A;A 57%
  • Han Chinese (Beijing)G;G 2% A;G 19% A;A 79%
  • Japanese (Tokyo)G;G <1% A;G 12% A;A 87%
  • Yoruba (Nigeria)G;G 10% A;G 43% A;A 47%
  • African ancestry (Southwest US)G;G 11% A;G 34% A;A 55%
  • Chinese (Denver)G;G <1% A;G 18% A;A 81%
  • Gujarati IndianG;G 12% A;G 45% A;A 44%
  • Luhya (Kenya)G;G 7% A;G 43% A;A 50%
  • Mexican ancestry (Los Angeles)G;G 9% A;G 56% A;A 35%
  • Maasai (Kenya)G;G 18% A;G 49% A;A 33%
  • TuscanG;G 15% A;G 33% A;A 52%

Conditions, medicines and genes

Other TBX21 SNPs

All TBX21 SNPs

Notes

From SNPedia

Notes

rs2074190(G;G) and rs2074190(A;G) genotypes for the TBX21 gene are calculated to be at 2.19 fold higher risk (CI: 1.27-3.77) for aspirin-induced asthma (AIA) compared to rs2074190(A;A) homozygotes, based on a study of 72 patients vs 640 controls in a study of a Japanese population. Note that in this population, but perhaps not others, linkage disequilibrium exists between this SNP located in the first exon, rs2074190, and a SNP located upstream of the gene, rs4794067, with a predictive accuracy of 92%.

Source and license

Adapted from rs2074190 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.