rs16947078

A SNP in the TBX21 gene on chromosome 17. Its most notable genotype is A;A: common

Gene
TBX21
Location
Chr 1747,748,134 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedcommonTypical · 0.075% of people
  2. A;GNot ratedpossible risk for allergic asthmaTypical · 0.023% of people
  3. G;GNot rated8x risk for allergic asthmaTypical · 0.02% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 75% A;G 23% G;G 2%
  • European ancestry (Utah)A;A 62% A;G 35% G;G 3%
  • Han Chinese (Beijing)A;A 97% A;G 3% G;G 0%
  • Japanese (Tokyo)A;A 97% A;G 3% G;G 0%
  • Yoruba (Nigeria)A;A 59% A;G 40% G;G 1%
  • African ancestry (Southwest US)A;A 70% A;G 30% G;G 0%
  • Chinese (Denver)A;A 98% A;G 2% G;G 0%
  • Gujarati IndianA;A 77% A;G 21% G;G 2%
  • Luhya (Kenya)A;A 73% A;G 25% G;G 3%
  • Mexican ancestry (Los Angeles)A;A 67% A;G 33% G;G 0%
  • Maasai (Kenya)A;A 60% A;G 38% G;G 2%
  • TuscanA;A 62% A;G 26% G;G 13%

Conditions, medicines and genes

Other TBX21 SNPs

All TBX21 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

A large study of Caucasian children has identified this SNP in the TBX21 gene (and one other, rs11650354) as defining a haplotype associated with increased risk for allergic asthma. The odds ratio associated with rs16947078(G;G) homozygotes compared to rs16947078(A;A) homozygotes for allergic asthma is reported to be 8.13 (CI: 2.5-26.9). Heterozygotes may be at slightly higher risk.

Source and license

Adapted from rs16947078 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.