rs4794067

A SNP in the TBX21 gene on chromosome 17. Its most notable genotype is C;C: 2.1x risk for Aspirin Induced Asthma. But possibly lower risk of lupus and intractable Graves' disease.

Gene
TBX21
Location
Chr 1747,731,462 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated2.1x risk for Aspirin Induced Asthma. But possibly lower risk of lupus and intractable Graves' disease.Worth knowing · 2.07% of people
  2. C;TNot rated2.1x risk for Aspirin Induced Asthma. But possibly lower risk of intractible Grave's disease.Minor · 1.933% of people
  3. T;TNot ratedLower risk of Aspirin Induced Asthma. Normal (higher) risk of lupus and intractable Grave's Disease.Minor · 1.161% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 7% C;T 33% T;T 61%
  • European ancestry (Utah)C;C 4% C;T 39% T;T 57%
  • Han Chinese (Beijing)C;C 3% C;T 21% T;T 76%
  • Japanese (Tokyo)C;C <1% C;T 14% T;T 85%
  • Yoruba (Nigeria)C;C 1% C;T 27% T;T 72%
  • African ancestry (Southwest US)C;C 7% C;T 30% T;T 63%
  • Chinese (Denver)C;C 2% C;T 19% T;T 79%
  • Gujarati IndianC;C 12% C;T 44% T;T 45%
  • Luhya (Kenya)C;C 5% C;T 30% T;T 66%
  • Mexican ancestry (Los Angeles)C;C 10% C;T 55% T;T 35%
  • Maasai (Kenya)C;C 13% C;T 47% T;T 40%
  • TuscanC;C 15% C;T 33% T;T 52%

Conditions, medicines and genes

Other TBX21 SNPs

All TBX21 SNPs

Notes

From SNPedia

Show notes, about 190 words

rs4794067(C;C) and rs4794067(C;T) genotypes for the TBX21 gene are calculated to be at 2.15 fold higher risk (CI: 1.26-3.64) for aspirin-induced asthma (AIA) compared to rs4794067(T;T) homozygotes, based on a study of 72 patients vs 640 controls in a study of a Japanese population. Note that in this population, but perhaps not others, linkage disequilibrium exists between this SNP located upstream of the gene, rs4794067, and a common synonymous SNP located in the first exon, rs2074190, with a predictive accuracy of 92%. On the other hand, rs4794067(C;C) may greatly decrease the risk of lupus if rs17250932(C;C) is also present (at least in Chinese people). And those 2 SNPs also reduce the risk of intractable Graves' disease (at least in Japanese people).

C;C

Only tested in Asians. Might not be true for other races.

C;T

Only tested in Japanese people. Might not be true for other races. May also be slightly protective against lupus (in Chinese people).

T;T

This is the normal version. It doesn't cause Aspirin Induced Asthma, but it doesn't reduce the risk of lupus or Grave's disease either like the rare version does.

Source and license

Adapted from rs4794067 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.