rs17250932

A SNP in the TBX21 gene on chromosome 17. Its most notable genotype is C;C: Reduced risk of lupus and intractable Graves' disease.

Gene
TBX21
Location
Chr 1747,731,941 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodReduced risk of lupus and intractable Graves' disease.Worth knowing · 2.0
  2. C;TGoodPossibly reduced risk of lupus and intractable Graves' disease.Minor · 1.7
  3. T;TBadNormal. Not protective against lupus and intractable Graves' disease.Minor · 1.1

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other TBX21 SNPs

All TBX21 SNPs

Notes

From SNPedia

Notes

C;C

This lowers the risk of lupus, and increases the chance of remission in Graves' disease. But it may also require rs4794067(C;C) to have the effect. Only verified in Asians.

C;T

This might lower the risk of lupus, and increase the chance of remission in Graves' disease. But it may also require rs4794067(C;C) to have the effect. Only verified in Asians.

T;T

Only verified in Asians.

References

Source and license

Adapted from rs17250932 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.