rs11650354

A SNP in the TBX21 gene on chromosome 17. Its most notable genotype is T;T: 8x risk for allergic asthma

Gene
TBX21
Location
Chr 1747,744,726 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.079% of people
  2. C;TBadpossible risk for allergic asthmaMinor · 1.119% of people
  3. T;TMost notableBad8x risk for allergic asthmaWorth knowing · 2.02% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 79% C;T 19% T;T 2%
  • European ancestry (Utah)C;C 66% C;T 31% T;T 3%
  • Han Chinese (Beijing)C;C 86% C;T 13% T;T <1%
  • Japanese (Tokyo)C;C 95% C;T 5% T;T 0%
  • Yoruba (Nigeria)C;C 83% C;T 16% T;T <1%
  • African ancestry (Southwest US)C;C 77% C;T 23% T;T 0%
  • Chinese (Denver)C;C 91% C;T 8% T;T <1%
  • Gujarati IndianC;C 67% C;T 31% T;T 2%
  • Luhya (Kenya)C;C 82% C;T 16% T;T 2%
  • Mexican ancestry (Los Angeles)C;C 74% C;T 26% T;T 0%
  • Maasai (Kenya)C;C 82% C;T 17% T;T 1%
  • TuscanC;C 66% C;T 24% T;T 11%

Conditions, medicines and genes

Other TBX21 SNPs

All TBX21 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

A large study of Caucasian children has identified this SNP in the TBX21 gene (and one other, rs16947078) as defining a haplotype associated with increased risk for allergic asthma. The odds ratio associated with rs11650354(T;T) homozygotes compared to rs11650354(C;C) homozygotes for allergic asthma is reported to be 8.13 (CI: 2.5-26.9). Heterozygotes may be at slightly higher risk.

Source and license

Adapted from rs11650354 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.