rs2305480

A SNP in the GSDMB gene on chromosome 17. Its most notable genotype is A;G: 3.5x increase in risk of asthma for Han Chinese

Gene
GSDMB
Location
Chr 1739,905,943 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.054% of people
  2. A;GMost notableBad3.5x increase in risk of asthma for Han ChineseWorth knowing · 2.037% of people
  3. A;ABadif 4 years old or younger, ~3x increased asthma risk if exposed to smokeWorth knowing · 2.010% of people

SNPedia records rs2305480 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 54% A;G 37% A;A 10%
  • European ancestry (Utah)G;G 27% A;G 51% A;A 21%
  • Han Chinese (Beijing)G;G 44% A;G 46% A;A 10%
  • Japanese (Tokyo)G;G 52% A;G 40% A;A 8%
  • Yoruba (Nigeria)G;G 90% A;G 10% A;A <1%
  • African ancestry (Southwest US)G;G 58% A;G 35% A;A 7%
  • Chinese (Denver)G;G 54% A;G 39% A;A 6%
  • Gujarati IndianG;G 42% A;G 47% A;A 12%
  • Luhya (Kenya)G;G 85% A;G 15% A;A <1%
  • Mexican ancestry (Los Angeles)G;G 38% A;G 45% A;A 17%
  • Maasai (Kenya)G;G 73% A;G 26% A;A 1%
  • TuscanG;G 28% A;G 52% A;A 20%

Conditions, medicines and genes

Other GSDMB SNPs

All GSDMB SNPs

Notes

From SNPedia

Notes

rs2305480 is one of several SNPs from a region on chromosome 17q21 that has been linked to risk for asthma. A total of 651 French patients with asthma, from among 1,621 subjects in 388 families, were analyzed for SNPs in the (17q21) region. An association was found between this SNP and early-onset asthma (but not with later onset asthma) which was significant after correction at p < 0.001. Upon further study, this association was seen primarily only in children exposed to tobacco smoke. The odds ratio was 2.77, based on the most likely assumption that this risk is associated only with the recessive homozygous state (and not the heterozygous state, which is still possible).

Source and license

Adapted from rs2305480 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.