rs7216389

A SNP in the GSDMB gene on chromosome 17. Its most notable genotype is C;C: 0.69x lower risk of Childhood Asthma.

Gene
GSDMB
Location
Chr 1739,913,696 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
37%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood0.69x lower risk of Childhood Asthma.Worth knowing · 2.011% of people
  2. C;TNot ratedNormal risk for Childhood Asthma.Minor · 1.840% of people
  3. T;TBad1.5x increased risk for Childhood Asthma.Worth knowing · 2.049% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 11% C;T 40% T;T 49%
  • European ancestry (Utah)C;C 24% C;T 55% T;T 21%
  • Han Chinese (Beijing)C;C 10% C;T 47% T;T 43%
  • Japanese (Tokyo)C;C 8% C;T 41% T;T 51%
  • Yoruba (Nigeria)C;C 2% C;T 20% T;T 78%
  • African ancestry (Southwest US)C;C 9% C;T 42% T;T 49%
  • Chinese (Denver)C;C 7% C;T 39% T;T 54%
  • Gujarati IndianC;C 17% C;T 46% T;T 38%
  • Luhya (Kenya)C;C 2% C;T 21% T;T 77%
  • Mexican ancestry (Los Angeles)C;C 17% C;T 45% T;T 38%
  • Maasai (Kenya)C;C 3% C;T 30% T;T 68%
  • TuscanC;C 21% C;T 55% T;T 25%

Conditions, medicines and genes

Other GSDMB SNPs

All GSDMB SNPs

Notes

From SNPedia

Notes

rs7216389, a SNP in the ORMDL3 gene on chromosome 17q21, was associated with susceptibility to childhood asthma in a study of ~1,000 British patients. The variation appears to be linked to altered levels of the ORMDL3 mRNA, which was shown in a cohort study of ~5,000 British and German patients to be correlated to childhood asthma. A large study of Scottish asthma patients replicated these results, finding that a single copy of the T allele conferred an odds ratio of 1.50 (CI: 1.24-1.81) and 2 copies conferred an odds ratio of 2.11 (CI: 1.71-2.61), respectively.

Source and license

Adapted from rs7216389 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.