rs2251746

rs2251746 is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases. An examination of over 11,000 Germans led to the conclusion that rs2251746 (and one other FCER1A SNP, the tightly linked rs2427837) were strongly associated with high levels of serum IgE. The more common (T) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous rs2251746(C;C) individuals may be at lower risk for atopic eczema and asthma than carriers of one or two (T) alleles. In Japanese patients, rs2251746 may be a poor predictor, and the neighboring rs2427827 may be more appropriate. Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients. Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.