rs2427837
A SNP in the FCER1A gene on chromosome 1. Its most notable genotype is A;A: lowest IgE levels
- Gene
- FCER1A
- Location
- Chr 1159,288,755 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 15%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedlowest IgE levels
- A;GNot ratedlower IgE levels
- G;GNot ratednormal but highest IgE levels
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 2% A;G 19% G;G 79%
- European ancestry (Utah)A;A 7% A;G 46% G;G 48%
- Han Chinese (Beijing)A;A 0% A;G 9% G;G 91%
- Japanese (Tokyo)A;A 0% A;G 11% G;G 89%
- Yoruba (Nigeria)A;A 2% A;G 8% G;G 90%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs2427837 is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases. An examination of over 11,000 Germans led to the conclusion that rs2427837 (and one other FCER1A SNP, the tightly linked rs2251746) were strongly associated with high levels of serum IgE. The more common (G) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous rs2251746(G;G) individuals may be at higher risk for atopic eczema and asthma than carriers of one or two (A) alleles.
Source and license
Adapted from rs2427837 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.