rs2303067

A SNP in the SPINK5 gene on chromosome 5. Its most notable genotype is A;A: 1.8x risk

Gene
SPINK5
Location
Chr 5148,101,392 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated1.8x riskTypical · 0.037% of people
  2. A;GNot rated?Typical · 0.044% of people
  3. G;GNot ratednormalTypical · 0.018% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 37% A;G 44% G;G 18%
  • European ancestry (Utah)A;A 26% A;G 52% G;G 22%
  • Han Chinese (Beijing)A;A 29% A;G 46% G;G 25%
  • Japanese (Tokyo)A;A 27% A;G 57% G;G 16%
  • Yoruba (Nigeria)A;A 65% A;G 32% G;G 3%
  • African ancestry (Southwest US)A;A 51% A;G 42% G;G 7%
  • Chinese (Denver)A;A 21% A;G 54% G;G 25%
  • Gujarati IndianA;A 26% A;G 53% G;G 22%
  • Luhya (Kenya)A;A 65% A;G 28% G;G 7%
  • Mexican ancestry (Los Angeles)A;A 14% A;G 35% G;G 52%
  • Maasai (Kenya)A;A 56% A;G 38% G;G 6%
  • TuscanA;A 29% A;G 54% G;G 17%

Conditions, medicines and genes

Other SPINK5 SNPs

All SPINK5 SNPs

Notes

From SNPedia

Show notes, about 120 words

rs2303067, a SNP in the SPINK5 gene, has been significantly associated with susceptibility to atopic dermatitis. The risk allele for rs2303067 is (A). rs2303067 has also been associated with predisposition to asthma, . From this study: "A significant association between rs2303067 and the development of asthma was observed (OR 1.77; 95%CI: 1.02-3.06, P=0.041 for rs2303067(A;A) homozygotes). Atopic carriers of rs2303067 showed an increased risk for asthma and asthma symptoms (OR 2.06; 95%CI: 1.01-4.20, P=0.047). When children with a combination of asthma and atopic dermatitis were compared with normal controls, the rs2303067(A) genotype was more prevalent in the disease group (OR 4.56; 95%CI: 1.370-15.12, P=0.007)."

Source and license

Adapted from rs2303067 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.