rs5067

A SNP in the NPPA gene on chromosome 1. Its most notable genotype is A;A: normal

Gene
NPPA
Location
Chr 111,845,924 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormalTypical · 0.070% of people
  2. A;GNot rated0.5x reduced risk for asthmaTypical · 0.025% of people
  3. G;GGood0.5x reduced risk for asthmaTypical · 0.05% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 70% A;G 25% G;G 5%
  • European ancestry (Utah)A;A 73% A;G 27% G;G <1%
  • Han Chinese (Beijing)A;A 99% A;G <1% G;G 0%
  • Japanese (Tokyo)A;A 97% A;G 3% G;G 0%
  • Yoruba (Nigeria)A;A 33% A;G 46% G;G 21%
  • African ancestry (Southwest US)A;A 37% A;G 53% G;G 11%
  • Chinese (Denver)A;A 99% A;G <1% G;G 0%
  • Gujarati IndianA;A 76% A;G 22% G;G 2%
  • Luhya (Kenya)A;A 45% A;G 46% G;G 10%
  • Mexican ancestry (Los Angeles)A;A 83% A;G 14% G;G 3%
  • Maasai (Kenya)A;A 47% A;G 45% G;G 9%
  • TuscanA;A 78% A;G 22% G;G 0%

Conditions, medicines and genes

Other NPPA SNPs

All NPPA SNPs

Notes

From SNPedia

Notes

rs5067 is a SNP in the natriuretic peptide precursor A NPPA gene. In a study of ~500 asthma patients, rs5067(G) were at reduced (50% or 76%) risk; the odds ratio in the first and second populations were 0.5 (CI: 0.29-0.84, p=0.009) and 0.24 (CI: 0.11-0.53, p<0.0001), respectively. The population-attributable risk for asthma in carriers of the rs5067(G) allele was 23.3%.

Source and license

Adapted from rs5067 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.