rs3804100

A SNP in the TLR2 gene on chromosome 4. Its most notable genotype is C;C: somwhat increased risk for type-1 diabetes and allergic asthma

Gene
TLR2
Location
Chr 4153,704,257 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedsomwhat increased risk for type-1 diabetes and allergic asthmaTypical · 0.02% of people
  2. C;TNot ratedsomewhat increased risk for type-1 diabetes and allergic asthmaTypical · 0.022% of people
  3. T;TGoodnormalTypical · 0.076% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 2% C;T 22% T;T 76%
  • European ancestry (Utah)C;C 0% C;T 14% T;T 86%
  • Han Chinese (Beijing)C;C 5% C;T 53% T;T 42%
  • Japanese (Tokyo)C;C 2% C;T 45% T;T 53%
  • Yoruba (Nigeria)C;C 0% C;T 11% T;T 89%
  • African ancestry (Southwest US)C;C 0% C;T 12% T;T 88%
  • Chinese (Denver)C;C 11% C;T 36% T;T 53%
  • Gujarati IndianC;C 1% C;T 24% T;T 75%
  • Luhya (Kenya)C;C 0% C;T 13% T;T 87%
  • Mexican ancestry (Los Angeles)C;C 0% C;T 16% T;T 84%
  • Maasai (Kenya)C;C <1% C;T 5% T;T 95%
  • TuscanC;C 1% C;T 14% T;T 85%

Conditions, medicines and genes

Other TLR2 SNPs

All TLR2 SNPs

Notes

From SNPedia

Notes

rs3804100, also known as 1350T/C, is a SNP in the toll-like receptor 2 TLR2 gene. A study of 700 T1D children, 357 nuclear families with T1D children and 796 children from the 'Environment and Childhood Asthma' study concluded that both type-1 diabetes and allergic asthma were significantly associated with the rs3804100(T) allele.

Source and license

Adapted from rs3804100 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.