rs4129267(T;T)

Associated with 73% higher IL-R and CRP levels

Magnitude
1.2Minor
Repute
Bad
Frequency
11%Average of 11 populations
On SNPedia
rs4129267(T;T)
Gene
IL6R

Frequency

Share of people with T;T in each HapMap population.

  • Mexican ancestry (Los Angeles)31%
  • Chinese (Denver)22%
  • Han Chinese (Beijing)15%
  • Japanese (Tokyo)14%
  • Tuscan14%
  • European ancestry (Utah)13%
  • Gujarati Indian3%
  • Maasai (Kenya)3%
  • Yoruba (Nigeria)<1%
  • African ancestry (Southwest US)0%
  • Luhya (Kenya)0%

Other genotypes of rs4129267

  1. C;CGoodNo increased risk of higher IL-R and CRP levelsMinor · 1.054% of people

All about rs4129267

Notes

From SNPedia

A 2012 educational article explained that in autoimmune inflammatory conditions, IL-6 promotes antibody production, drives CRP levels, and has other pathological roles. A 2013 article titled "Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci" stated that TT homozygous at rs4129267 had sIL-6R (soluble inhibiting IL-6 receptors) concentrations 73% higher than CC homozygous (28.9 versus 16.7 ng/ml; P = 7.8 × 10−17) and CRP (C-reactive protein) concentrations were 30% higher in TT than in CC (19.2 versus 14.8 mg/l). See further references at rs4129267

References

Source and license

Adapted from rs4129267(T;T) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.