rs569108

A SNP in the MS4A2 gene on chromosome 11. Its most notable genotype is T;T.

Gene
MS4A2
Location
Chr 1160,095,631 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
12%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. G;GNot rated?Typical · 0.04% of people
  3. A;GBad3x risk of predisposition to childhood asthma in a Japanese populationTypical · 0.023% of people
  4. A;AGoodnormalTypical · 0.073% of people

SNPedia records rs569108 on the minus strand: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 0% G;G 4% A;G 23% A;A 73%
  • European ancestry (Utah)T;T 0% G;G 0% A;G 10% A;A 90%
  • Han Chinese (Beijing)T;T 0% G;G 5% A;G 31% A;A 65%
  • Japanese (Tokyo)T;T 0% G;G <1% A;G 30% A;A 70%
  • Yoruba (Nigeria)T;T 0% G;G 7% A;G 28% A;A 65%
  • African ancestry (Southwest US)T;T 0% G;G 4% A;G 33% A;A 63%
  • Chinese (Denver)T;T 0% G;G 5% A;G 29% A;A 66%
  • Gujarati IndianT;T 0% G;G 0% A;G 5% A;A 95%
  • Luhya (Kenya)T;T 0% G;G 10% A;G 47% A;A 43%
  • Mexican ancestry (Los Angeles)T;T 0% G;G 2% A;G 5% A;A 93%
  • Maasai (Kenya)T;T 0% G;G 7% A;G 29% A;A 64%
  • TuscanT;T 0% G;G 0% A;G 9% A;A 91%

Conditions, medicines and genes

Other MS4A2 SNPs

All MS4A2 SNPs

Notes

From SNPedia

Show notes, about 140 words

rs569108, a SNP in the MS4A2 gene, has been linked in a Japanese population to a predisposition to childhood asthma, with an odds ratio of 3 PMID 8842731, PMID 8968765. The risk allele in dbSNP orientation is (C). [Note: no (C;C) homozygotes were observed in this population.] Gene-environment interaction effects on the development of immune responses in the 1st year of life. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. A candidate gene association study of 77 polymorphisms in migraine.

Source and license

Adapted from rs569108 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.