rs2278206

A SNP in the INPP4A gene on chromosome 2. Its most notable genotype is A;A: 1.16x increased risk for asthma

Gene
INPP4A
Location
Chr 298,555,781 (GRCh38)
Highest magnitude
1.8Minor
Tested on
23andMe
Minor allele frequency
28%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TNot ratedNo summary available.Typical · 0.00% of people
  2. G;GGoodpossibly less susceptible to asthmaMinor · 1.68% of people
  3. A;GNot ratednormalTypical · 0.039% of people
  4. A;AMost notableBad1.16x increased risk for asthmaMinor · 1.853% of people

SNPedia records rs2278206 on the minus strand: (A;G), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;T 0% G;G 8% A;G 39% A;A 53%
  • European ancestry (Utah)C;T 0% G;G 5% A;G 35% A;A 59%
  • Han Chinese (Beijing)C;T 0% G;G 9% A;G 37% A;A 54%
  • Japanese (Tokyo)C;T 0% G;G 8% A;G 43% A;A 49%
  • Yoruba (Nigeria)C;T 0% G;G 3% A;G 26% A;A 71%
  • African ancestry (Southwest US)C;T 0% G;G 9% A;G 37% A;A 54%
  • Chinese (Denver)C;T 0% G;G 9% A;G 38% A;A 53%
  • Gujarati IndianC;T 0% G;G 9% A;G 46% A;A 46%
  • Luhya (Kenya)C;T 0% G;G 13% A;G 43% A;A 45%
  • Mexican ancestry (Los Angeles)C;T 0% G;G 2% A;G 50% A;A 48%
  • Maasai (Kenya)C;T 0% G;G 10% A;G 40% A;A 51%
  • TuscanC;T 0% G;G 11% A;G 40% A;A 49%

Conditions, medicines and genes

Notes

From SNPedia

Notes

A study of ~170 families led to a slight association between rs2278206 and atopic asthma. The risk genotype - in dbSNP orientation, not as published - is rs2278206(T;T). Conversely, the rs2278206(C;C) genotype was rarely (odds ratio 0.13) seen in patients with atopic asthma.

Source and license

Adapted from rs2278206 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.