rs1042713

A SNP in the ADRB2 gene on chromosome 5. Its most notable genotype is A;A: 1.7x increased risk that pediatric inhaler use may make asthma worse

Gene
ADRB2
Location
Chr 5148,826,877 (GRCh38)
Highest magnitude
1.7Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.7x increased risk that pediatric inhaler use may make asthma worseMinor · 1.724% of people
  2. A;GBad1.3x increased risk that pediatric inhaler use may make asthma worseMinor · 1.349% of people
  3. G;GNot ratednormalTypical · 0.027% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 24% A;G 49% G;G 27%
  • European ancestry (Utah)A;A 12% A;G 47% G;G 41%
  • Han Chinese (Beijing)A;A 32% A;G 53% G;G 15%
  • Japanese (Tokyo)A;A 21% A;G 46% G;G 33%
  • Yoruba (Nigeria)A;A 32% A;G 43% G;G 26%
  • African ancestry (Southwest US)A;A 32% A;G 51% G;G 18%
  • Chinese (Denver)A;A 30% A;G 51% G;G 18%
  • Gujarati IndianA;A 19% A;G 51% G;G 31%
  • Luhya (Kenya)A;A 24% A;G 50% G;G 26%
  • Mexican ancestry (Los Angeles)A;A 19% A;G 55% G;G 26%
  • Maasai (Kenya)A;A 28% A;G 52% G;G 21%
  • TuscanA;A 16% A;G 42% G;G 42%

Conditions, medicines and genes

Other ADRB2 SNPs

All ADRB2 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 160 words

rs1042713, also known as Arg16, G16R, and 16Arg>Gly, is a SNP in the adrenergic, beta-2-, surface receptor ADRB2 gene. The rs1042713(G) allele encodes the G/glycine form that is the more common one in most populations, while rs1042713(A) encodes the R/arginine residue at this position of the ADRB2 protein. A study of 1,182 young Scottish asthma patients (age, 3-22 years) concluded that rs1042713(A) alleles are significantly associated with "exacerbations" of their condition, regardless of treatment regimens (odds ratio 1.30, CI: 1.09-1.55, p=0.003). This didn't hold true for patients using inhalers less than once per day; and it was particularly true for those receiving daily inhaled long- or short-acting beta(2)-agonist treatment (OR, 1.64, CI: 1.22-2.20, p=.001). This may therefore indicate that regular inhalant use may be counter-productive in young asthma patients carrying one or especially two rs1042713(A) alleles.

Source and license

Adapted from rs1042713 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.