rs1800888
A SNP in the ADRB2 gene on chromosome 5. Its most notable genotype is T;T: increased risk of coronary artery disease
- Gene
- ADRB2
- Location
- Chr 5148,827,322 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodnormal
- C;TBadincreased risk of coronary artery disease
- T;TMost notableBadincreased risk of coronary artery disease
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 7 HapMap populations.
- AverageC;C 99% C;T 1% T;T 0%
- European ancestry (Utah)C;C 98% C;T 2% T;T 0%
- Han Chinese (Beijing)C;C 99% C;T <1% T;T 0%
- Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
- Yoruba (Nigeria)C;C 100% C;T 0% T;T 0%
- Luhya (Kenya)C;C 99% C;T <1% T;T 0%
- Mexican ancestry (Los Angeles)C;C 98% C;T 2% T;T 0%
- TuscanC;C 98% C;T 2% T;T 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 170 words
rs1800888, also known as Ile164, is a SNP in the beta 2 adrenergic receptor ADRB2 gene. The rs1800888(T) encodes the much rarer Ile allele. In a study of 330 patients undergoing percutaneous coronary intervention (PCI), patients carrying a rs1800888(T) allele showed a higher incidence of new acute myocardial infarction (17.5% vs. 4.5%, p = 0.001), new PCI (37.5% vs. 13.1%, p < 0.0001), and cardiac death (10% vs. 3.1%, p = 0.036). Regression analysis identified rs1800888(T) as an independent predictor of cardiac death (odds ratio 3.731, CI: 1.004 - 13.867, p = 0.049) and an overall major adverse cardiac event (odds ratio 4.1, CI: 1.945 - 8.640, p = 0.0001). A replication study was done on a population of 150 patients with peripheral artery disease. The presence of the rs1800888(T) allele was associated with a higher incidence of acute myocardial infarction (54.5% vs. 25.2%, p = 0.035) or combined events (acute myocardial infarction, PCI, or coronary artery bypass graft) (63.6% vs. 30.9%, p = 0.027).
Source and license
Adapted from rs1800888 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.