rs4585

A SNP in the ATM gene on chromosome 11. Its most notable genotype is G;G: slightly higher (1.35x) odds of good metformin response in type 2 diabetics

Gene
ATM
Location
Chr 11108,368,901 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodslightly higher (1.35x) odds of good metformin response in type 2 diabeticsWorth knowing · 2.028% of people
  2. G;TNot ratedaverage response to metformin in type 2 diabeticsWorth knowing · 2.045% of people
  3. T;TBadslightly poorer (0.75x) response to metformin in type 2 diabeticsMinor · 1.527% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 28% G;T 45% T;T 27%
  • European ancestry (Utah)G;G 19% G;T 54% T;T 27%
  • Han Chinese (Beijing)G;G 33% G;T 46% T;T 22%
  • Japanese (Tokyo)G;G 35% G;T 43% T;T 22%
  • Yoruba (Nigeria)G;G 28% G;T 59% T;T 13%
  • African ancestry (Southwest US)G;G 32% G;T 41% T;T 28%
  • Chinese (Denver)G;G 29% G;T 51% T;T 20%
  • Gujarati IndianG;G 10% G;T 38% T;T 52%
  • Luhya (Kenya)G;G 48% G;T 42% T;T 10%
  • Mexican ancestry (Los Angeles)G;G 18% G;T 44% T;T 39%
  • Maasai (Kenya)G;G 47% G;T 41% T;T 12%
  • TuscanG;G 13% G;T 33% T;T 54%

Conditions, medicines and genes

Other ATM SNPs

All ATM SNPs

Notes

From SNPedia

Notes

rs4585 has been found to modify the metformin response in patients with type 2 diabetes. Metformin Response

Source and license

Adapted from rs4585 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.