rs2144908

Affects type-2 diabetes popular in pubmed Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians. Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial. Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4alpha gene and insulin secretion index in Thais. Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women. Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans. Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. A common P2 promoter polymorphism of the hepatocyte nuclear factor-4alpha gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes. Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population. Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population. Association of novel variants in the hepatocyte nuclear factor 4A gene with maturity onset diabetes of the young and early onset type 2 diabetes.