rs137853336
A SNP in the HNF4A gene on chromosome 20. Its most notable genotype is C;T: associated with MODY1; maturity onset of diabetes in the young (type 1)
- Gene
- HNF4A
- Location
- Chr 2044,413,714 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;TMost notableBadassociated with MODY1; maturity onset of diabetes in the young (type 1)
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other HNF4A SNPs
- rs137853334C;Tassociated with MODY1; maturity onset of diabetes in the young (type 1)Worth knowing
- rs137853335C;Tassociated with MODY1; maturity onset of diabetes in the young (type 1)Worth knowing
- rs137853337A;Gassociated with MODY1; maturity onset of diabetes in the young (type 1)Worth knowing
- rs137853338G;Tassociated with MODY1; maturity onset of diabetes in the young (type 1)Worth knowing
- rs587777732C;Tassociated with MODY1; maturity onset of diabetes in the young (type 1)Worth knowing
- rs745975C;Ccommon in clinvarTypical
- rs1800961C;Ccommon in complete genomicsTypical
- rs1885088G;GNo summary available.Typical
Notes
From SNPedia
Notes
aka c.406C>T (p.Arg136Trp or R136W); known in older literature as c.340C>T (p.Arg114Trp or R114W) A 2019 study of >300,000 UK BioBank participants of European ancestry concluded that while this variant is associated with a higher risk of diabetes (OR 2.9, CI: 1.7-5.0, p=3x1-e-4), the penetrance was estimated to be <10%. Therefore, if this variant is seen in a diabetic, it might be the primary cause, but incidental discovery of the variant in a healthy (non-diabetic) individual is of little predictive value. See also OMIM 600281.0003
Source and license
Adapted from rs137853336 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.