rs3772534

A SNP in the CBLB gene on chromosome 3. Its most notable genotype is G;G.

Gene
CBLB
Location
Chr 3105,702,190 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
4%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. C;CGoodcommon in complete genomicsTypical · 0.089% of people

SNPedia records rs3772534 on the minus strand: (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageG;G 0% C;C 89%
  • European ancestry (Utah)G;G 0% C;C 96%
  • Han Chinese (Beijing)G;G 0% C;C 80%
  • Japanese (Tokyo)G;G 0% C;C 70%
  • Yoruba (Nigeria)G;G 0% C;C 100%
  • Chinese (Denver)G;G 0% C;C 83%
  • Gujarati IndianG;G 0% C;C 86%
  • Mexican ancestry (Los Angeles)G;G 0% C;C 97%
  • Maasai (Kenya)G;G 0% C;C 98%
  • TuscanG;G 0% C;C 96%

Conditions, medicines and genes

Notes

From SNPedia

Notes

One report based on a study of 480 Danish families indicated that the rs3772534 SNP in the CBLB gene indicated an increased risk for developing type 1 diabetes, and that there might be co-inheritance with the rs3087243 SNP found in the CTLA4 gene. However, a subsequent study based on over 2,000 parent-child trios (ie families) failed to find any evidence of either effect.

Source and license

Adapted from rs3772534 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.