rs104894006
A SNP in the GCK gene on chromosome 7. Its most notable genotype is A;G: Diabetes, late-onset noninsulin-dependent (predicted)
- Gene
- GCK
- Location
- Chr 744,149,992 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadDiabetes, late-onset noninsulin-dependent (predicted)
SNPedia records rs104894006 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other GCK SNPs
- rs1799884T;T2.7x increased risk for Type 2 Diabetes. Mothers have babies 54g heavier.Important
- rs80356654A;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs80356655A;Gassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894005A;Cassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894008C;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894009C;Gassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894011A;Cassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894016C;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
Notes
From SNPedia
Notes
aka c.556C>T (p.Arg186Ter or R186X) This mutation is a very rare variant strongly associated with late-onset noninsulin-dependent diabetes (odds ratio ~68, CI: 14-328, p = 2x10e-8); see ClinVar and OMIM links.
A;G
see text and links via main rs-page
Source and license
Adapted from rs104894006 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.