rs80356654
A SNP in the GCK gene on chromosome 7. Its most notable genotype is A;T: associated with MODY2; maturity onset of diabetes in the young (type 2)
- Gene
- GCK
- Location
- Chr 744,149,810 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- A;TMost notableBadassociated with MODY2; maturity onset of diabetes in the young (type 2)
- A;AGoodcommon in clinvar
SNPedia records rs80356654 on the minus strand: (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other GCK SNPs
- rs104894006A;GDiabetes, late-onset noninsulin-dependent (predicted)Very important
- rs1799884T;T2.7x increased risk for Type 2 Diabetes. Mothers have babies 54g heavier.Important
- rs80356655A;Gassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894005A;Cassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894008C;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894009C;Gassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894011A;Cassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
- rs104894016C;Tassociated with MODY2; maturity onset of diabetes in the young (type 2)Worth knowing
Notes
From SNPedia
Notes
Neonatal diabetes mellitus due to complete glucokinase deficiency.
Source and license
Adapted from rs80356654 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.